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P B B R

Program for Breakthrough Biomedical Research

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About The Program for Breakthrough Biomedical Research (PBBR)


Daring ideas are like chessmen moving forward. They may be beaten, but they may start a winning game.
-Johann Wolfgang von Goethe

The Program for Breakthrough Biomedical Research (PBBR) seeks to stimulate and support highly innovative basic science research at UCSF. The focus is on basic science projects of potentially high impact that are creative, risky, and transformative. We seek novel ideas for basic science projects that are more ambitious than those that receive funding from NIH and other traditional funding mechanisms.

The Program for Breakthrough Biomedical Research is currently in its remarkable sixteenth year. Investigators credit the Program for Breakthrough Biomedical Research with engendering over $500 million in subsequent grant funding, and projects and their derivatives have resulted in 1,500 scientific publications and dozens of patents.

Scientist quotes about the Program for Breakthrough Biomedical Research:

The Program for Breakthrough Biomedical Research provides a model for how to empower scientists to take calculated risks and reach for the stars, enabling them to make the transformative discoveries that are the real engines of scientific advance. It is a much needed antidote to the current research funding mechanisms that reward conservative research and avoid risk-taking, and penalize young investigators. As a grateful recipient of one of the program's grants back in the late 90s, I applaud UCSF for preserving and expanding this important funding mechanism.

Marc Tessier-Lavigne, PhD
The Rockefeller University president and head of the Laboratory of Brain Development

A sustained and solid attack is needed for opening up new types of research. Support from the Program for Breakthrough Biomedical Research gives interdisciplinary work a critically important jump start, allowing new directions for collaborative groups not generally funded by federal research funds.

Elizabeth Blackburn, PhD
UCSF Professor of Biochemistry & Biophysics
Nobel Prize in Physiology or Medicine, 2009

Featured PBBR publications:

Lishko, PV, Botchkina, IL, Fedorenko, A, Kirichok, Y. Acid Extrusion from Human Spermatozoa is Mediated by Flagellar Voltage-Gated Proton Channel. Cell. 2010 Feb 5;140(3):327-37.Science-2012-Shohat-Ophir-1351-5.pdf (Click here for PDF)

Shohat-Ophir, G, Kaun, KR, Azanchi, R, Mohammed, H, Heberlein, U. Sexual Deprivation Increases Ethanol Intake in Drosophila. Science. 2012 Mar 16;335(6074):1351-5. (Click here for PDF)

The Program for Breakthrough Biomedical Research is operated at the University of California San Francisco.