The PBBR Laureates

Each year, the Program for Breakthrough Biomedical Research (PBBR) supports dozens of investigators whose bold ideas and revolutionary research have the potential to drive unprecedented advances in science and medicine. Here, you can find a comprehensive list of the most recent recipients of PBBR’s assorted prizes, as well as a brief description of their PBBR-funded projects.

2015 - 2016

New Frontiers Research Awards

Adam Frost
New concepts for understanding and treating neurodegenerative disease

Bassem Al-Sady and Shaeri Mukherjee 

Host chromatin reprogramming with a single bacterial histone methylase effector RomA and its lessons for chromatin biology

Benjamin Braun and Neil Shah

A high content screen to decode apoptosis regulation and signal transduction in cancer

Bo Huang and Noelle L'Etoile

Visualizing RNA polymerase II engaged in RNA-dependent interfering RNA biogenesis

Charlie Kim

Monocyte-mediated immunoregulation during Plasmodium infection

Christian Vaisse, Jeremy Reiter, and Mark Von Zastrow
Controlling long-term regulation of energy homeostasis through cilia specific neuronal signaling in vivo

Danica Fujimori and Shingo Kajimura

Metabolic rewiring in brown adipose tissue

Dengke Ma

Establishing "Vertebrate C. elegans" to discover novel mechanisms of extreme physiology

Edward Hsiao

Identifying novel neuronal links in a disease of abnormal bone formation

Evan Feinberg

Deciphering sensory responses of dopamine neurons

Geeta Narlikar

Conformation-specific antibodies for mapping and modulating nucleosome conformations in vivo

Ian Seiple

Platform for the discovery of novel pleuromutilin Antibiotics

Jacquelyn Maher and Aras Mattis

Development of an in vitro model of human non-alcoholic fatty liver disease using hepatocyte-like cells

JJ Miranda

Next-generation antivirals: dual mechanism inhibitors

Joachim Li

Exploring a role for replication timing in epigenetic inheritance

Kaveh Ashrafi

Unexpected effects of common insecticides on circadian rhythms and feeding

Keith Mostov and Jeremy Reiter
Novel ciliary signaling controls intestinal length

Kira Poskanzer

Seeing the extracellular space: nanosensors for astrocyte-neuron biology

Lani Wu

How do different alpha-synuclein varients affect human neuron-astrocyte interactions?

Mark Looney

The lung is a site of platelet biogenesis and a niche for hematopoietic stem cells

Michael German, Robert Blelloch, Ingrid Block-Kurbisch, Susan Fisher, Michael McManus, and Kirsten Salmeen

Assaying circulating placental exosomes

Michael Keiser

Decoding emergent pharmacology in cells and whole organisms

Michael Oldham

Modeling low-grade glioma in cerebral organoids using Cas9 ribonucleoproteins

Nadav Ahituv

Functional characterization of early neuronal enhancers

Natalia Jura and Ophir Klein

Canopies as novel chaperones of fibroblast growth factor receptors

Nevan Krogan and R. Kate Kelley

Translation intergration of genomic and viral interaction data in hepatocellular carcinoma

Peter Turnbaugh and Joseph Bondy-Denomy

Editing the human gut microbiome for precision medicine

Raul Andino

Profiling exosomal small RNAs for viral infection diagnosis and prognosis in immunocompromised patients

Rik Derynck, Danica Galonic Fujimori, and Nevan Krogan

Intracellular signaling control by arginine demethylation

Rushika Perera

Novel genetic models to interrogate organelle function in cancer

Sourav Bandyopadhyay

Chemical-genetic interations maps to guide cancer chemotherapy

Steven Altschuler

Reverse engineering brain wiring of the fly visual system

Suneil Koliwad and Mervyn Maze

A strategy that targets microglia to reduce cognitive decline following surgery

Tejal Desai and Lawrence Fong

Oncolytic virus inspired nanoparticle based intratumoral immunotherapy for prostate cancer

Willian Degrado

FLAMES (Fluorescent Amyloid Multiple Emission Spectra) microscopy for the determination of distinct strains of amyloids and prions

YW Kan

Elevation of fetal hemoglobin for the treatment of sickle cell anemia and beta thalassemia

Zev Gartner

Tissue morphing: a paradigm shift for organ regeneration

Technologies, Methodogies & Cores

Charles Craik
Robotic overture 96-channel peptide synthesizer for peptide-enabled technologies at UCSF

Evan Feinberg

A novel genetic approach to map, monitor, and manipulate synaptic circuits

Jason Cyster and Susan Fisher

Lipid mass spectrometry core

Rosemary Akhurst

Acquisition of high resolution computer tomograph-guided X-irradiator for Helen Diller Family Comprehensive Cancer Center Preclinical Therapeutic Core Facility

William Weiss and James Wells

Recombinant antibody probes for next-generation cytometry platforms