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The PBBR Laureates

Each year, the Sandler Program for Breakthrough Biomedical Research (PBBR) supports dozens of investigators whose bold ideas and revolutionary research have the potential to drive unprecedented advances in science and medicine. Here, you will find a comprehensive list of the most recent recipients of PBBR’s assorted research awards as well as a brief description of their PBBR-funded projects. For a list of Sandler Fellowship recipients, which are also PBBR-supported, please visit the Sandler Fellows Program website

 

New Frontier Research (NFR) Awards
2025

Wallace Marshall, PhD: The role of physical packing in driving organelle interactions.

Wendy Yue, PhD: Exploring pain processing in African spiny mice: unveiling endogenous analgesic mechanisms.

Orion Weiner, PhD: Next-generation synthetic biology: hybrid computational/biological interfaces to reprogram and understand cell function.

Qili Liu, PhD: Integrative regulation of nitrogen flux.

Todd Nystul, PhD, and John Vaughen, PhD: Rapid and flexible multigenic perturbations in genetically defined cells.

Andrew Yang, PhD, and Alma Burlingame, PhD: Revealing the blood-brain barrier as an immunological window into the brain.

Dengke Ma, PhD: Pausing and restarting life from reversible suspended animation.

Holly Ingraham, PhD, and Wendy Yue, PhD: Probing brain-body crosstalk in maternal physiology.

Babak Javid, MB BChir, PhD, and Magnus Hoffmann, PhD: mRNA subunit vaccines encoding self-assembling nanoparticles for tuberculosis.

Mark Pownall, PhD, and Bo Huang, PhD: Dynamics and functional consequences of de novo heterochromatin formation during vertebrate embryogenesis.

Kelsey Collins, PhD: Designer adipose tissue: a novel stem cell therapy strategy for obesity.

Danica Galonić Fujimori, PhD: Non-inducing antibiotics as a novel strategy to prevent antibiotic resistance.

Sara Suliman, MPH, PhD: CRISPR/Cas9 screen to identify macrophage transcriptional states associated with Mycobacterium tuberculosis susceptibility.

Erica Hutchins, PhD: An RNA-centered strategy for engineering cell fate.

Hiten Madhani, MD, PhD, and Hanna Martens, PhD: Stopping the aging clock.

Stephen Nishimura, MD, and Yifan Cheng, PhD: Role of dynamic allostery in cell-cell signaling in the immunologic synapse.

Jeannette Tenthorey, PhD: High-throughput identification of self-inhibitory viral peptides.

Hanna Martens, PhD: New strategies to label cellular neighborhoods affected by paracrine signaling.

Daniel Lim, MD, PhD: Proximity of DNA to nuclear pores: a spatial genome organization model for activity-dependent gene expression in neurons.

Bo Huang, PhD: Cell cycle regulation of cytoplasmic condensates and condensate aging.

Jose Angel Nicolas Avila, PhD: Unravelling the molecular mechanisms involved in heterophagy regulation.

Kaveh Ashrafi, PhD, and Vijay Namboodiri, PhD: Investigating a neglected hormone: a novel strategy to enhance learning and memory.

Beth Winger, MD, PhD, and Natalia Jura, PhD: Transforming kinase inhibitor selection for kinase variant cancers.

Daniel Minor, Jr, PhD, and Adam Renslo, PhD: Development of K2P channel chemical biology.

Amar Nijagal, MD, and Adam Abate, PhD: Developing customized microfluidic droplet ensembles to study cell-cell interactions in the developing liver.

Diego Calderon, PhD, and Su Guo, PhD: Building a cross-species model that predicts cell type-specific enhancer activity through scalable characterization of regulatory elements in vivo.

Alexis Combes, PhD, and Michael Alexanian, PhD: Identifying novel epigenetic and transcriptional regulators of pathological macrophages in heart failure using CRISPR screens.

2024

Evan Feinberg, PhD: Buttons, not knobs: testing a new hypothesis for brain-spinal cord interactions in motor control.

Param Priya Singh, PhD: Developing an organ complementation paradigm for aging.

Tyson Kim, MD, PhD, and Xin Duan, PhD: Vascular chaperones: a novel mechanism for perivascular neurons in regulating retinal blood flow.

Noelle L'Etoile, PhD, and Carly Demopoulos, PhD: Remote sensing of biologically relevant charge fluxes through magnetosensation.

Bassem Al-Sady, PhD, and Tanja Kortemme, PhD: Bottom-up reconstruction of chromatin domains with designed proteins.

Leanne Jones, PhD: Multi-dimensional assessment of lipid metabolism during aging and neurodegeneration.

Ian Seiple, PhD, and Balyn Zaro, PhD: Expanding the ligandability of the proteome.

Katherine Susa, PhD, and Jim Wells, PhD: Deciphering the activation mechanism of FcεR1 on mast cells.

Raul Andino, PhD, Adam Abate, PhD, and Michel Tassetto, PhD: Massive parallel cloning of chimeric proteins: building a new generation of programmable recombinases for biomedical genome editing.

David Booth, PhD: Re-designing animal hormones to visualize metabolic functions in microbial communities.

Alexander (Sandy) Johnson, PhD: Interplay between eukaryotic and bacterial microbes in gnotobiotic mice.

Devanand Manoli, MD, PhD: Representing relationships: the neuronal mechanisms of social bonds.

Nadav Ahituv, PhD, and Chris Diederich, PhD: Controlling gene expression with ultrasound.

Peter Turnbaugh, PhD, and Andrew Yang, PhD: Microbial control of the blood-brain barrier.

Robert Edwards, MD: The substrate of synaptic vesicle protein 2.

Jennifer Fung, PhD: A chemical biology approach to understanding meiosis.

Vasanth Vedantham, MD, PhD, Abigail Buchwalter, PhD, Matthew Kutys, PhD, and Arun Padmanabhan, MD, PhD: Nuclear mechanobiology of arrhythmia and cardiomyopathy: a tissue engineering approach.

Jeroen Roose, PhD, and Karin Pelka, PhD: Dissecting spatially organized multicellular interaction networks in cancer.

Kevin Yackle, MD, PhD: The learned control of breathing.

Dengke Ma, PhD, and Orion Weiner, PhD: A new synthetic approach to manipulate membrane tension and enhance cell resilience.

Mark von Zastrow, MD, PhD, Vijay Namboodiri, PhD, and Aliza Ehrlich, PhD: Identifying spatiotemporal dopamine dynamics at neuronal primary cilia and their impact on neuromodulation in behaving animals.

Ritchie Chen, PhD, and Saul Villeda, PhD: A high-throughput screen for prophylactic factors to treat age-related cognitive decline.

Markus Delling, PhD: Lessons learned from cystic fibrosis: polycystin correctors as a novel therapeutic approach for autosomal dominant polycystic kidney disease.

Roarke Kamber, PhD: Deciphering the molecular basis of phagocytic failure modes.

Geeta Narlikar, PhD: Using cryo-electron tomography to investigate the internal structure of heterochromatin phases.

Roshanak Irannejad, PhD, and Aashish Manglik, MD, PhD: Signaling in the right place and the right time: molecular and cellular interrogation of anti-obesity drugs.

Qili Liu, PhD: Extending lifespan by targeting homeostatic protein feeding.

Su Guo, PhD: Developing technologies to uncover molecular and cellular basis of motivated behavior variation.

Trevor Fidler, PhD: Mechanisms of macrophage fate in atherosclerosis.

Anatoly Urisman, MD, PhD, and Gregory Ku, MD, PhD: CRISPR-Sec-MS: a protein barcoding strategy for CRISPR screens for protein secretion.

2023

Fred Chang, MD, PhD: Probing the viscoelastic properties of the cytoplasm using optical tweezers.

Xin Duan, PhD, and Evan Feinberg, PhD: Investigating axon regeneration at synaptic resolution.

Angela Phillips, PhD: Biophysical constraints on antibody affinity maturation.

Seth Shipman, PhD, and James Fraser, PhD: Multiplexing structural determination using retron reverse-transcribed DNA.

Michael McManus, PhD: Multiplex CRISPR delivery by living cells.

Hao Li, PhD, and Martin Kampmann, PhD: "Curing" Alzheimer's disease via transcriptional reprogramming.

Alexander (Sandy) Johnson, PhD: Using the bacterium Pseudomonas aeruginosa to develop new strategies to combat world-wide fungal pathogens.

Wendell Lim, PhD, and Faranak Fattahi, PhD: Harnessing synthetic cell adhesion molecules to improve the efficiency of myelination by hPSC-derived Schwann cells.

Mazen Kheirbek, PhD, and Eric Collisson, MD: Neural circuits for depression-related behavior in pancreatic ductal adenocarcinoma.

Young-wook Jun, PhD: Interrogation of in vivo tissue mechanics during pathogenesis using single mechanoMR microparticles.

Maxence Nachury, PhD: Tools to study the transfer of ciliary material via extracellular vesicles in vivo.

Kyle Cromer, PhD: Development of inducible signaling receptors to increase production of clinically relevant cell types.

Erica Hutchins, PhD: In vivo visualization and identification of de novo translation.

Isha Jain, PhD, and Andrei Goga, MD, PhD: Rusting metastases with oxygen toxicity.

Matthew Kutys, PhD, and Joel Ernst, MD: 3D biomimetic human tuberculosis granulomas for innovative therapies.

Willow Coyote-Maestas, PhD, Jeremy Reiter, MD, PhD, Gabriel Loeb, MD, PhD, and Markus Delling, PhD: Towards a systematic understanding of Polycystin basic biology and disease.

Emily Goldberg, PhD: Can a histone deacetylase operate in reverse?

Jennifer Rosenbluth, MD, PhD, and Nadav Ahituv, PhD: Bioengineering adipocytes for breast cancer therapy.

Pamela England, PhD, and Deepak Lamba, MD, PhD: Developing synthetic PNR ligands for the treatment of retinal degeneration.

David Solomon, MD, PhD: Tackling cancers driven by genomic haploidization.

Carlo Condello, PhD, and Adam Abate, PhD: In situ exploration of dysregulated lipid metabolism and cellular vulnerability in Alzheimer's mice with integrative multi-omics.

Hani Goodarzi, PhD, and Caroline Vissers, PhD: Who watches the watchmen? An upstream look at the epitranscriptome.

Ying-Hui Fu, PhD: Interrogating a role for fatty acid metabolites in driving sleep/wake cycles.

Stephen Floor, PhD: Synthetic cell-type specific control of protein synthesis by RNA-binding proteins.

Laura Hertel, PhD: 3-D modeling of the human pharyngeal mucosa.

Johannes Kratz, MD, and Michael Wilson, MD: High-resolution epitope mapping of early-stage lung cancer.

2022

Dengke Ma, PhD, Yin Shen, PhD, and Shaeri Mukherjee, PhD: A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience.

Mustafa Aydogan, PhD, and Bruce Alberts, PhD: Unravelling a mitochondrial oxidant signal that acts as a metabolic switch at the onset of morphogenesis.

Abigail (Abby) Buchwalter, PhD: Turnover and replication analysis by isotope labeling (TRAIL) defines protein and cell lifetimes in vivo.

Margaux Pinney, PhD, and William DeGrado, PhD: Establishment of a high-throughput microfluidic assay to dissect the function of the E protein from SARS-CoV-2.

Evan Feinberg, PhD: A new paradigm for investigating everyday movements.

Noelle L'Etoile, PhD: Robust collective behavior: the bidirectional self-organizing spiral.

Orion Weiner, PhD, and Diana Laird, PhD: Probing the role of mechanotransduction in embryo dysfunction of aged mothers.

Michael McManus, PhD: Transforming array based screening.

Daniel Minor, Jr, PhD, and Gregory Ku, MD, PhD: Characterization of a 'dark' endoplasmic reticulum chloride channel.

Allison Xu, PhD: Tanycyte-to-neuron differentiation as a mechanism of neuronal plasticity for setting the body adiposity set point.

Robert Stroud, PhD: Developing a new paradigm to visualize cellular complexes in their native environments.

Graeme Davis, PhD, and Jeanne Paz, PhD: Controlling post-traumatic neurodegeneration and epileptogenesis.

John Gross, PhD, and Ruth Huettenhain, PhD: Deciphering the molecular mechanism of NLRP1 inflammasome activation by ubiquitination.

David Julius, PhD: Understanding the physiological function of cerebrospinal fluid-contacting neurons in the mammalian spinal cord.

Andrew Yang, PhD, and Alma Burlingame, PhD: A bioorthogonal approach to discover brain-derived antigens in health and disease.

Roshanak Irannejad, PhD, and Ruth Huttenhain, PhD: Understanding dopamine signaling from the Golgi apparatus in spiny projection neurons.

Aashish Manglik, MD, PhD: Cracking the olfactory code: biophysical and structural interrogation of odorant receptors.

Joseph Bondy-Denomy, PhD: Determining the mechanism of protein import into a phage "nucleus".

Shuvo Roy, PhD, and Julie Sneddon, PhD: Isolation and characterization of adult human pancreatic islet-derived extracellular vesicles utilizing an in vivo cell culture system.

Raul Andino, PhD, and Michel Tassetto, PhD: Viral surface displayed nanobody: from programmable tissue-specific gene therapy delivery to synthetic Nab library screening platform.

Faranak Fattahi, PhD, and Bjoern Schwer, PhD: A humanized mouse model of the enteric nervous system.

Robert Blelloch, MD, PhD: Cross-dressing as a driver in the anti-tumor immune response.

Reza Abbasi Asl, PhD: Revealing regionalization in whole-organ spatial datasets via interpretable machine learning.

Jan Christoph, PhD: Artificial intelligence-assisted imaging and prediction of heart rhythm disorders using high-speed four-dimensional (4D) ultrasound.

Wendell Lim, PhD: Laying a cellular trap: a "handshake" sensor to identify and target autoreactive antigen specific T cells.

Tanja Kortemme, PhD, and Michael Keiser, PhD: Deep-learning guided de novo design of protein functions.

2021

Vijay Ramani, PhD, and Diana Laird, PhD: Developmental origin and single cell heterogeneity of repeat expansion disease.

Barbara Panning, PhD: Challenging the paradigm of Xist RNA function.

John Gross, PhD, and Corie Ralston, PhD: Deciphering the conformational control of enzyme activity in biological condensates.

Edward Hsiao, MD, PhD, Xiaobing Yu, MD, and Mark Petersen, MD: Elucidating a novel link between neurological disease and heterotopic ossification via ACVR1.

Reza Abbasi Asl, PhD: Revealing neural functions in primary visual cortex via interpretable and biologically realistic neural networks.

Bassem Al-Sady, PhD, and Hana El-Samad, PhD: Exploiting evolution to create synthetic repressive epigenetic circuits.

Joel Ernst, MD, and John Metcalfe, MD: Enabling dual single cell RNA sequencing of host and intracellular pathogens.

Fred Chang, MD, PhD: How carnivorous fungi trap their prey.

Robert Stroud, PhD: Developing a new paradigm to treat an autoimmune disease.

Devanand Manoli, MD, PhD: Defining the neural and molecular substrates of social attachment.

Andy Chang, PhD: Physiological functions of atypical mitochondrial electron transport chain subunits.

Maxence Nachury, PhD, and Jeremy Reiter, PhD: Gene therapy for Bardet-Biedl syndrome-associated retinal degeneration.

Suzanne Noble, MD, PhD: Meiosis-specific proteins in an organism without meiosis.

Margaret Feeney, MD, and Susan Fisher, PhD: Maternofetal transfer of pathogen-derived antigens: a novel mass spectrometry approach.

Oren Rosenberg, MD, PhD, and Joanne Engel, MD, PhD: Host-pathogen Gen2EM: multiresolution visualization of an intracellular pathogen and its host.

Eric Collisson, MD, Natalia Jura, PhD, and John Gordan, MD, PhD: A framework for validating pseudokinase drug targets to enhance tumor suppression.

Sophie Dumont, PhD: Uncovering the basis of tissue architecture in the simplest multicellular animal.

Evan Feinberg, PhD: Developing a new paradigm for coordination.

Sarah Knox, PhD, and Julie Sneddon, PhD: Nerve plasticity and function in pancreatic disease and regeneration.

Charles Chiu, MD, PhD: Development and validation of novel machine learning algorithms for diagnosis of human diseases.

Orion Weiner, PhD, and Shawn Douglas, PhD: Engineering cell shape with DNA origami.

Anna Molofsky, MD, PhD, and Scott Baraban, PhD: Establishing a zebrafish model system to study microglial-synapse dynamics during brain development.

Mustafa Aydogan, PhD, and Patrick O'Farrell, PhD: Tackling the intrinsic developmental clock that times and triggers cellularization.

David Booth, PhD: Propelling choanoflagellate genome engineering to discover the origins of animal cell differentiation.

2020 and Earlier

 

Technologies, Methodologies, and Cores (TMC) Awards
2025

Michelle Arkin, PhD, and Charles Hart, PhD: Request for a next-generation mass spectrometry screening platform with the SCIEX Echo MS+ for the Small Molecule Discovery Center Core.

Joseph Bondy-Denomy, PhD: Microbial liquid culture in high throughput.

Eric Chow, PhD, Ryan Corces, PhD, Thuy Doan, PhD, and Michael Wilson, MD: Expanding genomics capabilities at UCSF.

Matthew Spitzer, PhD, and Karin Pelka, PhD: Cellanome instrument for multiplexed functional, imaging-based, and multi-omics analysis of individual and interacting cells.

2024

Wendell Lim, PhD, and Kari Herrington, PhD: Live cell light sheet microscope facility for the UCSF Center for Advanced Light Microscopy.

Ritchie Chen, PhD, Allan Basbaum, PhD, Cathryn Cadwell, MD, PhD, Xin Duan, PhD, Douglas Gould, PhD, Tomasz Nowakowski, PhD, and Vasanth Vedantham, MD, PhD: Hydrogel tissue chemistries for molecular mapping across cells, tissues, and organs.

Orion Weiner, PhD, Fred Chang, MD, PhD, Sophie Dumont, PhD, Dyche Mullins, PhD, Mark von Zastrow, MD, PhD, Zev Gartner, PhD, and Torsten Wittman, PhD: Enabling fast, gentle, and convenient 4D fluorescence imaging at UCSF.

Kelsey Collins, PhD, and Biao Wang, PhD: Modernizing dual energy X-ray absorptiometry at UCSF.

Zev Gartner, PhD: A next generation 4D organoid bioprinter.

Willow Coyote-Maestas, PhD: Image-based cellular sorting for transformative cellular biology.

Geeta Narlikar, PhD, Orion Weiner, PhD, Sophie Dumont, PhD, Bassem Al-Sady, PhD, Fred Chang, MD, PhD, and Dyche Mullins, PhD: Enabling use of correlated optical tweezers and confocal microscopy at UCSF.

2023

Jennifer Fung, PhD, and Michelle Arkin, PhD: Request for an Opera Phenix Plus to replace two soon-to-be-sunsetted rapid high content confocal imaging platforms used in three cores (SMDC, CCC, and EARTH Center).

Jason Sello, PhD, and Matthew McCarroll, PhD: Multi-camera array microscope (MCAM) system.

Allison Xu, PhD, and Tiffany Scharschmidt, MD: High throughput cell metabolism at Parnassus.

Torsten Wittmann, PhD: Oblique plane single objective light sheet microscopy for mammalian organoids.

Faranak Fattahi, PhD, Tomasz Nowakowski, PhD, and Alex Pollen, PhD: The UCSF Organoid Competency Hub.

Susan Lynch, PhD: A high throughput microbial single-cell isolation platform for translational research.

Emily Goldberg, PhD, and Balyn Zaro, PhD: Mission Bay spectral flow cytometer.

2022

Eric Chow, PhD, Thuy Doan, PhD, Hani Goodarzi, PhD, Tomasz Nowakowski, PhD, Vijay Ramani, PhD, and Jimmie Ye, PhD: Accessing higher throughput and lower cost post-Illumina sequencing with an Ultima Genomics UG100.

Mary Helen Barcellos-Hoff, PhD, Jean-Philippe Coppé, PhD, Thea Tlsty, PhD, Chloe Atreya, MD, PhD, John Gordan, MD, PhD, Lani Wu, MD, PhD, Neil Shah, MD, PhD, Julia Carnevale, MD, PhD, Deanna Kroetz, PhD, Michelle Arkin, PhD, Susan Fisher, PhD, and Saul Villeda, PhD: Phospho-reactome mapping system: transformative technology to interrogate kinase circuits.

John Gross, PhD, and Mark Kelly, PhD: Replacement of the magnet pumping system (BMPC) for the 800 MHz NMR magnet in the UCSF NMR Laboratory.

Susan Lynch, PhD: Mass spectrometry instruments for Quantitative Metabolite Analysis Center.

2021

Tom Kornberg, PhD, and David Agard, PhD: Acquisition of a Leica CryoUltramicrotome to enable EM of cryo-preserved tissue.

Arturo Alvarez-Buylla, PhD, Susan Fisher, PhD, Corey Harwell, PhD, Arnold Kriegstein, MD, PhD, Mercedes Paredes, MD, PhD, Alex Pollen, PhD, and Holger Willenbring, MD, PhD: Automated subcellular resolution spatial transcriptomics for the interrogation of cell types, cell states, and cell interactions.

Jonathan Esensten, MD, PhD, Alexander Marson, MD, PhD, Kole Roybal, PhD, and Justin Eyquem, PhD: Pipeline for generation of novel therapeutic T cell products by CRISPR-Cas9 genome editing.

Matthew Krummel, PhD, Jimmie Ye, PhD, Gabriela Fragiadakis, PhD, Walter Eckalbar, PhD, and Kyle Marchuk, PhD: A platform for “bleeding-edge” spatial transcriptomic technologies.

Charles Chiu, MD, PhD, Steve Miller, MD, PhD, Melanie Ott, MD, PhD, Chaz Langelier, MD, PhD, Michael Wilson, MD, Adam Abate, PhD, Theodore Ruel, MD, Joe DeRisi, PhD, and Jim Wells, PhD: Establishment of a novel COVID-19 clinical diagnostic testing core at UCSF.

2020 and Earlier

 

Postdoc Independent Research Awards
2025

Sagar Bhattacharya, PhD: De novo design of radium-binding proteins.

Caroline Doherty, PhD: Optogenetic manipulation to increase soma-supplied products necessary for oocyte maturation.

Allegra Freelander, PhD: Cell-surface interrogation of bone metastases using seeding-on-a-chip approaches.

Ankitha Shetty, PhD: A novel spatial approach to investigate clonal T cell behavior in diseased tissues.

Ernest Lee, MD, PhD: Computational discovery of novel therapeutics for hidradenitis suppurativa.

Varun Suresh, PhD: Molecular circuitry of social behavior: from amygdala projections to autism spectrum disorder (ASD) pathophysiology.

Mia Konjikusik, PhD: How signaling at the primary cilium regulates neuronal output in feeding behaviors.

Lilian Gomes de Oliveira, PhD: Impact of congenital antiviral immune responses on medial ganglionic eminence development and epileptogenesis.

Jery Joy, PhD: In vivo characterization of p3 peptide, Aβ17-42, in Drosophila central nervous system.

2024

Caroline Escoubas, MD, PhD: Elucidating the role of neuronal double strand DNA breaks during cortical development.

Élora Midavaine, PhD: Sex chromosomal contribution to lymphocyte regulation of neuropathic pain.

Jan Lebert, PhD: Noninvasive cardiac pacing with focused ultrasound.

Joy Karmakar, PhD: Selective fluorescent sensor for “zombie drug” xylazine.

Kelsey DeFrates, PhD: Investigating the effect of mechanical strain on Pseudomonas aeruginosa during biofilm formation.

Makoto Nakamura, PhD: Uncovering a novel pathway in atrial fibrillation through calcium channel modulation.

Mengyi Song, PhD: Dissecting cell type-specific gene regulation in human cortical neural progenitors at single-cell resolution.

Olive Burata, PhD: Engineering bacterial transporters for enhanced lycopene production and tolerance using a collaborative approach of directed evolution and biophysical characterization.

Ran Cao, PhD: Defining novel mechanisms of cytokine release from astrocytes and neurons via CRISPR screen.

Sara Hadad, PhD: Automated brain tumor segmentation: generative AI and convolutional networks integration.

Wei Jiang, PhD: Inducible synthetic linkage of mitochondria-lysosome to promote longevity and healthspan.

Xinxin Ge, PhD: Molecular and functional properties of V1 neurons receiving bottom-up or top-down input.

Yangpeiwei Huang, PhD: Rejuvenation potential of targeting eIF4E-mediated proteostasis disruption.

2023

Alexandra Klein, PhD: Control of anxiety states and underlying neural dynamics by respiratory rhythms.

Brisa Palikuqi, PhD: Investigating the role of endothelial cells in intestinal regeneration and disease.

Chia-Hsiang Chang, MD, PhD: Discovery of novel cerebrospinal fluid (CSF) flow sensors in ependymal cilia.

Fangzhu Zhao, PhD: Comprehensive profiling of antiviral public antibodies using a high-throughput viral glycoprotein library.

Iain Martyn, PhD: Mapping single cell lineage histories, spatial locations, and transcriptional profiles together with CARTOGRAPHER in the developing mouse.

Jonathan Bayerl, PhD: Metabolic profiling of naked mole-rat fibroblasts and iPSCs for understanding regulation of social cast transitions and longevity in eusocial super agers.

Mary Mirvis, PhD: Comparative cell anatomy through evidence synthesis.

Murat Can Kalem, PhD: Investigation of temperature sensing by RNA thermometers in Histoplasma.

Nicholas Kuhn, PhD: Proteomic analysis of fibroblast-derived proteins in tumors.

Sakeen Kashem, MD, PhD: Regulatory T cell control of pain sensitivity.

Shenliang Yu, PhD: Systematic identification of gut amino acid sensors that regulate hunger and satiety.

Sujit Kashyap, PhD: ATF7ip-control of T cell tumor immune responses.

Tushar Raskar, PhD: Capturing translation stalling in cells using in situ cryo-electron tomography.

Xiaofang Zhong, PhD: Profiling of protein-carbohydrate interactions by GECX-sugar for cancer biomarker discovery.

Xiaoxin Chen, PhD: Deciphering a novel transcriptional program governing cerebellar granule neuron progenitor proliferation and primary cilium formation.

Yuda Chen, PhD: Switchable G protein-coupled receptor (GPCR) activation by antibody-antigen recognition.

2022

Arja Ray, PhD: Defining and targeting hyper-reactive CD8 T cells in autoimmune type 1 diabetes.

Christina Homer, MD, PhD: Investigation of the role of subtilases in the parasitic phase of Coccidioides.

Federica Liccardo, PhD: Development of bio-orthogonal ceramide-based voltage-sensitive fluorophores to interrogate subcellular changes in membrane potential.

Finn Wolfreys, DPhil: Intrabody-enabled phenotypic screening for novel protein folding chaperones.

Homa Majd, PhD: Defining the cell type specific role of mitochondria in diabetes associated metabolic stress in the gut.

Jing Hui Adeline Yong, PhD: Identifying the activity-associated postsynaptic proteome.

Lei Lu, PhD: Drug discovery targeting metalloenzymes with ligand docking and de novo protein design.

Maxime Kinet, MD, PhD: Inflammatory imprinting of Th2-interacting fascial fibroblasts.

Miquel Rosas Salvans, PhD: Understanding microtubule coordination at large kinetochores of holocentric chromosomes.

Nina Serwas, PhD: Organellar tropism of Mycobacterium tuberculosis in humans and mice.

2021

Brittany Moser, PhD: Tracking of single cell-cell interactions for high-resolution mapping of emperipolesis.

Dan Piraner, PhD: Rapid generation of off-the-shelf CAR-T cells via genome-wide CRISPR modulation in induced pluripotent stem cells.

Ekaterina Korotkevich, PhD: Single cell mitochondrial DNA (mtDNA) and cell state profiling to identify mechanisms of age-dependent mutant mtDNAs accumulation and its effects on organismal fitness.

Hyunjun Yang, PhD: Spatio-temporal multimodal omic analysis of amyloid plaque-induced molecular phenotypes.

Joni Nikkanen, PhD: Targeting sex-specific hepatic factors to fight pathogens.

Saghi Sadoughi, PhD: Using time-lapse high-resolution peripheral quantitative computed tomography (HR-pQCT) to determine total bone turnover in patients with chronic kidney disease.

Simon Cleary, PhD: New radiotracers for noninvasive diagnosis of complement-mediated diseases.

Simon Kretschmer, PhD: Design of a multi-drug-controlled protein safety switch for synergistically modulating chimeric antigen receptor (CAR) T-cells and managing therapy-related adverse effects.

Swapnil Rohidas Shinde, PhD: Quality control of the photoreceptor outer segment.

Yuping Li, PhD: Understanding the genome organization of bacteriophage ΦKZ.

2020 and Earlier

 

COVID-19 Awards (Special 2020 Funding Opportunity)

Tanja Kortemme, PhD, and Aashish Manglik, MD, PhD: Super-ACEs: engineering ACE2-based and de novo proteins to prevent and treat SARS-CoV-2 infections.

Marina Sirota, PhD, and Chaz Langelier, MD, PhD: Transcriptomics-based computational drug repositioning for COVID-19 treatment.

Xiaokun Shu, PhD: Designing imaging reporters of the spike protein and ACE2 interaction for screening inhibitors that block SARS-CoV-2 entry into human cells.

Hana El-Samad, PhD: Viral pathogen detection by genetically encoded responses.

Aashish Manglik, MD, PhD, and Peter Walter, PhD: Aerosol-based passive immunization for SARS-CoV-2 using synthetic nanobodies.

Yifan Cheng, PhD, Charles Craik, PhD, and Aashish Manglik, MD, PhD: Structural basis of humoral immunity to the SARS-CoV-2 spike protein.

Cliff Lowell, MD, PhD, and Satish Pillai, PhD: Development of a novel mouse model of COVID-19 disease.

Zev Gartner, PhD: A high-throughput screening platform for identifying broadly neutralizing antibodies against SARS-CoV-2.

Nadia Roan, PhD, Sulggi Lee, MD, PhD, Joshua Vasquez, MD, and Eliver Ghosn, PhD: Characterization of B-cell and antibody responses associated with efficient recovery from COVID-19.

Jeremy Reiter, MD, PhD: Understanding and drugging SARS-CoV-2 NSP13.

Shaeri Mukherjee, PhD: Repurposing of the secretory and membrane trafficking pathway by SARS-CoV-2.

Koh Fujinaga, PhD, and Matjia Peterlin, MD: Identification of antiviral agents targeting SARS-CoV-2 replication.

Jim Wells, PhD: Development of recombinant antibodies for SARS-CoV-2 diagnostics and therapeutics.

John Gross, PhD, Brian Shoichet, PhD, and Jack Taunton, PhD: Discovery of small-molecule inhibitors of SARS-CoV-2 by targeting the essential enzyme Nsp16.

Melanie Ott, MD, PhD, and Michael McManus, PhD: Orthogonal CRISPR screens to identify COVID-19 polytherapies.

Michael Keiser, PhD: Learning the key molecular interactions of drug candidates targeting SARS-CoV-2 proteins.

David Morgan, PhD, FRS: Phosphoregulation of the SARS-CoV-2 nucleocapsid (N) protein.

Bill DeGrado, PhD, and Michael Grabe, PhD: De novo design of small proteins that bind the spike protein of SARS-CoV-2.

Bruce Wang, MD, Franklin Huang, MD, PhD, Michael Kattah, MD, PhD, and Tien Peng, MD: Transcriptomic features of cellular and tissue pathogenesis of SARS-CoV-2 infection in human tissues.

Diane Havlir, MD, Bryan Greenhouse, MD, and Gabriel Chamie, MD: SARS-CoV-2 transmission dynamics in longitudinal population-level assessments in the Mission District – “Fuerte San Francisco” Study.

Jeremy Reiter, MD, PhD, Melanie Ott, MD, PhD, David Erle, MD, and Semil Choksi, PhD: Mapping SARS-CoV-2 infection, replication, and transcriptional responses in human airway epithelial cells

Jack Taunton, PhD, Davide Ruggero, PhD, and Melanie Ott, MD, PhD: Targeting viral protein biogenesis as a therapeutic strategy for COVID-19.